Solvent-Controlled Leaving-Group Selectivity in Aromatic Nucleophilic Substitution
-
- Lukas Hintermann
- Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan
-
- Ritsuki Masuo
- Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan
-
- Keisuke Suzuki
- Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan
書誌事項
- 公開日
- 2008-10-09
- DOI
-
- 10.1021/ol801962a
- 公開者
- American Chemical Society (ACS)
この論文をさがす
説明
A solvent-controlled inversion of leaving group ability allows selective access to either of two internal substitution products in S(N)Ar reactions of substrates with competing leaving groups. Application of this principle in a selective synthesis of the highly functionalized xanthone core of the antibiotic FD-594 is presented.
収録刊行物
-
- Organic Letters
-
Organic Letters 10 (21), 4859-4862, 2008-10-09
American Chemical Society (ACS)