Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion
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- Achille Broggi
- Division of Immunology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 1
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- Francesca Granucci
- Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy 3
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- Ivan Zanoni
- Division of Immunology, Boston Children’s Hospital and Harvard Medical School, Boston, MA 1
説明
<jats:p>Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique traits that delineate them as primary protectors of barrier integrity at mucosal sites. This unique role stems both from the restricted expression of IFN-λ receptor, confined to epithelial cells and to a limited pool of immune cells, and from unique immunomodulatory properties of IFN-λ. Here, we discuss recent findings that establish the unique capacity of IFN-λ to act at the barriers of the host to balance tissue tolerance and immune resistance against viral and bacterial challenges.</jats:p>
収録刊行物
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- Journal of Experimental Medicine
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Journal of Experimental Medicine 217 (1), 2019-12-05
Rockefeller University Press
