Rvb1–Rvb2: essential ATP-dependent helicases for critical complexesThis paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

DOI Web Site Web Site 被引用文献2件
  • Jennifer Huen
    Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
  • Yoshito Kakihara
    Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
  • Francisca Ugwu
    Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
  • Kevin L. Y. Cheung
    Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
  • Joaquin Ortega
    Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
  • Walid A. Houry
    Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.

書誌事項

公開日
2010-02
権利情報
  • http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMining
DOI
  • 10.1139/o09-122
公開者
Canadian Science Publishing

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<jats:p> Rvb1 and Rvb2 are highly conserved, essential AAA+ helicases found in a wide range of eukaryotes. The versatility of these helicases and their central role in the biology of the cell is evident from their involvement in a wide array of critical cellular complexes. Rvb1 and Rvb2 are components of the chromatin-remodeling complexes INO80, Swr-C, and BAF. They are also members of the histone acetyltransferase Tip60 complex, and the recently identified R2TP complex present in Saccharomyces cerevisiae and Homo sapiens; a complex that is involved in small nucleolar ribonucleoprotein (snoRNP) assembly. Furthermore, in humans, Rvb1 and Rvb2 have been identified in the URI prefoldin-like complex. In Drosophila, the Polycomb Repressive complex 1 contains Rvb2, but not Rvb1, and the Brahma complex contains Rvb1 and not Rvb2. Both of these complexes are involved in the regulation of growth and development genes in Drosophila. Rvbs are therefore crucial factors in various cellular processes. Their importance in chromatin remodeling, transcription regulation, DNA damage repair, telomerase assembly, mitotic spindle formation, and snoRNP biogenesis is discussed in this review. </jats:p>

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