Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
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- Zhuo Chen
- Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Feng Miao
- Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Andrew D. Paterson
- Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada;
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- John M. Lachin
- The Biostatistics Center, The George Washington University, Rockville, MD 20852-3943;
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- Lingxiao Zhang
- Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Dustin E. Schones
- Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Xiwei Wu
- Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Jinhui Wang
- Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Joshua D. Tompkins
- Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Saul Genuth
- Case Western Reserve University, Cleveland, OH 44106
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- Barbara H. Braffett
- The Biostatistics Center, The George Washington University, Rockville, MD 20852-3943;
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- Arthur D. Riggs
- Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010;
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- Rama Natarajan
- Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010;
書誌事項
- 公開日
- 2016-05-09
- 権利情報
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- http://www.pnas.org/preview_site/misc/userlicense.xhtml
- DOI
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- 10.1073/pnas.1603712113
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>Vascular complications are the main cause of morbidity and mortality in the diabetic population. Clinical trials of diabetic complications show a persistence of benefit from early application of intensive therapy for glycemic control in diabetic patients, a phenomenon referred to as metabolic memory. The mechanisms underlying metabolic memory are not fully understood. In this study, using two groups of type 1 diabetic patients with and without complications development and two sets of genomic DNAs collected 16–17 y apart from the same patients, we showed a persistency of DNA methylation over time at key genomic loci associated with diabetic complications. These data provide direct evidence of a relationship between epigenetics (DNA methylation variations) and human metabolic memory, supporting an epigenetic mechanism.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 113 (21), E3002-, 2016-05-09
Proceedings of the National Academy of Sciences
