DNA MISMATCH REPAIR

DOI Web Site 被引用文献24件
  • Thomas A. Kunkel
    Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709;
  • Dorothy A. Erie
    Department of Chemistry and Curriculum in Materials Science, Venable and Kenan Laboratories, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290;

書誌事項

公開日
2005-06-01
DOI
  • 10.1146/annurev.biochem.74.082803.133243
公開者
Annual Reviews

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説明

<jats:p> ▪ Abstract  DNA mismatch repair (MMR) is an evolutionarily conserved process that corrects mismatches generated during DNA replication and escape proofreading. MMR proteins also participate in many other DNA transactions, such that inactivation of MMR can have wide-ranging biological consequences, which can be either beneficial or detrimental. We begin this review by briefly considering the multiple functions of MMR proteins and the consequences of impaired function. We then focus on the biochemical mechanism of MMR replication errors. Emphasis is on structure-function studies of MMR proteins, on how mismatches are recognized, on the process by which the newly replicated strand is identified, and on excision of the replication error. </jats:p>

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