Rho Kinases in Cardiovascular Physiology and Pathophysiology

DOI Web Site 28 Citations
  • Gervaise Loirand
    From the From INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.
  • Patrice Guérin
    From the From INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.
  • Pierre Pacaud
    From the From INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.

Abstract

<jats:p>Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Abnormal activation of the RhoA/ROCK pathway has been observed in major cardiovascular disorders such as atherosclerosis, restenosis, hypertension, pulmonary hypertension, and cardiac hypertrophy. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology.</jats:p>

Journal

  • Circulation Research

    Circulation Research 98 (3), 322-334, 2006-02-17

    Ovid Technologies (Wolters Kluwer Health)

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