Bioinspired Scaffolds with Varying Pore Architectures and Mechanical Properties

DOI Web Site Web Site 被引用文献4件
  • Michael M. Porter
    Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive, La Jolla CA 92093 USA
  • Russ Imperio
    Department of Mechanical and Aerospace Engineering University of California San Diego 9500 Gilman Drive, La Jolla CA 92093 USA
  • Matthew Wen
    Department of Mechanical and Aerospace Engineering University of California San Diego 9500 Gilman Drive, La Jolla CA 92093 USA
  • Marc A. Meyers
    Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive, La Jolla CA 92093 USA
  • Joanna McKittrick
    Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive, La Jolla CA 92093 USA

書誌事項

公開日
2013-12-04
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/adfm.201302958
公開者
Wiley

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説明

<jats:p>Scaffolds with potential biological applications having a variety of microstructural and mechanical properties can be fabricated by freezing colloidal solutions into porous solids. In this work, the structural and mechanical properties of TiO<jats:sub>2</jats:sub> freeze cast with different soluble additives, including polyethylene glycol, NaOH or HCl, and isopropanol alcohol, are characterized to determine the effects of slurry viscosity, pH, and alcohol concentration on the freezing process. TiO<jats:sub>2</jats:sub> powders mixed with water and these different additives are directionally frozen in a mold, then sublimated and sintered to create the porous scaffolds. The different scaffolds are characterized to compare the compressive strength, modulus, porosity, and pore morphology. For all scaffolds, the overall porosity remains constant (80–85%). By changing the concentration of each additive, the lamellar thickness, pore area, and aspect ratio vary significantly, showing inverse relationships to both the compressive strength and modulus. The strength is predicted from the pore aspect ratio of the scaffolds when subjected to compressive loading with the primary failure mode identified as Euler buckling. TiO<jats:sub>2</jats:sub> scaffolds freeze cast with different soluble additives are suitable for biomedical applications, such as bone replacements, requiring high porosity and specific pore morphologies.</jats:p>

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