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- Josep Lluís Melero-Ferrer
- Unidad de Cardiopatías Congénitas del Adulto, Servicio de Cardiología, Área Clínica del Corazón, Hospital Universitari i Politècnic La Fe, Valencia, España
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- Ana Osa-Sáez
- Unidad de Cardiopatías Congénitas del Adulto, Servicio de Cardiología, Área Clínica del Corazón, Hospital Universitari i Politècnic La Fe, Valencia, España
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- Francisco Buendía-Fuentes
- Servicio de Cardiología, Hospital Arnau de Vilanova, Valencia, Spain
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- Antonio Ballesta-Cuñat
- Área Clínica de Imagen Médica, Hospital Universitari i Politècnic La Fe, Valencia, España
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- Lucía Flors
- Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA, USA
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- María Rodríguez-Serrano
- Unidad de Cardiopatías Congénitas del Adulto, Servicio de Cardiología, Área Clínica del Corazón, Hospital Universitari i Politècnic La Fe, Valencia, España
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- Pilar Calvillo-Batllés
- Área Clínica de Imagen Médica, Hospital Universitari i Politècnic La Fe, Valencia, España
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- Miguel-Ángel Arnau-Vives
- Servicio de Cardiología, Hospital Universitari i Politècnic La Fe, Valencia, España
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- Miguel A. Palencia-Pérez
- Servicio de Cardiología, Hospital Universitari i Politècnic La Fe, Valencia, España
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- Joaquín Rueda-Soriano
- Unidad de Cardiopatías Congénitas del Adulto, Servicio de Cardiología, Área Clínica del Corazón, Hospital Universitari i Politècnic La Fe, Valencia, España
書誌事項
- タイトル別名
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- Acoustic Radiation Force Impulse Elastography as a Useful Tool for Liver Assessment
説明
<jats:sec><jats:title>Objective:</jats:title><jats:p> The development of liver fibrosis and cirrhosis due to long-standing liver congestion is known to occur in adult patients with Fontan circulation. Hepatic elastography has shown to be a useful tool for the noninvasive assessment and staging of liver fibrosis in chronic liver diseases, although the utility of this technique in Fontan patients remains to be adequately studied. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> Twenty-one patients with Fontan circulation underwent an abdominal ultrasound and an acoustic radiation force impulse (ARFI) elastography. In order to compare the results from this group, a cohort of 14 healthy controls and another group containing 17 patients with cirrhosis were included. The association between the velocity values measured with elastography and clinical and analytical parameters were also studied. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Mean shear waves propagation velocity in liver tissue in the Fontan group was 1.86 ± 0.5 m/s, with 76% of patients over the cirrhosis threshold (1.55 m/s). The control group had a mean velocity of 1.09 ± 0.06 m/s, while the cirrhotic group obtained 2.71 ± 0.51 m/s. Seven patients with Fontan circulation had increased liver enzymes. Liver ultrasound showed evidence of chronic liver disease in six patients. Velocity values obtained in the presence or absence of analytical or liver ultrasound abnormalities showed significant differences in the univariate analysis ( P = .04 and P = .03 respectively). </jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p> In conclusion, ARFI elastography showed increased wave propagation velocity values in the Fontan population suggesting increased liver stiffness which could be related to advanced fibrosis. A statistically significant association between ARFI values and the presence of analytical and ultrasound abnormalities has been demonstrated. </jats:p></jats:sec>
収録刊行物
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- World Journal for Pediatric and Congenital Heart Surgery
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World Journal for Pediatric and Congenital Heart Surgery 5 (3), 365-371, 2014-06-23
SAGE Publications