The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development
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- Anna Sorushanova
- Regenerative, Modular and Developmental Engineering Laboratory (REMODEL) Biomedical Sciences Building National University of Ireland Galway (NUI Galway) Galway Ireland
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- Luis M. Delgado
- Regenerative, Modular and Developmental Engineering Laboratory (REMODEL) Biomedical Sciences Building National University of Ireland Galway (NUI Galway) Galway Ireland
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- Zhuning Wu
- Regenerative, Modular and Developmental Engineering Laboratory (REMODEL) Biomedical Sciences Building National University of Ireland Galway (NUI Galway) Galway Ireland
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- Naledi Shologu
- Regenerative, Modular and Developmental Engineering Laboratory (REMODEL) Biomedical Sciences Building National University of Ireland Galway (NUI Galway) Galway Ireland
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- Aniket Kshirsagar
- Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM) Biomedical Sciences Building National University of Ireland Galway (NUI Galway) Galway Ireland
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- Rufus Raghunath
- Centre for Cell Biology and Tissue Engineering Competence Centre Tissue Engineering for Drug Development (TEDD) Department Life Sciences and Facility Management Institute for Chemistry and Biotechnology (ICBT) Zürich University of Applied Sciences Wädenswil Switzerland
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- Anne M. Mullen
- Teagasc Research Centre Ashtown Ireland
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- Yves Bayon
- Sofradim Production–A Medtronic Company Trevoux France
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- Abhay Pandit
- Science Foundation Ireland (SFI) Centre for Research in Medical Devices (CÚRAM) Biomedical Sciences Building National University of Ireland Galway (NUI Galway) Galway Ireland
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- Michael Raghunath
- Centre for Cell Biology and Tissue Engineering Competence Centre Tissue Engineering for Drug Development (TEDD) Department Life Sciences and Facility Management Institute for Chemistry and Biotechnology (ICBT) Zürich University of Applied Sciences Wädenswil Switzerland
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- Dimitrios I. Zeugolis
- Regenerative, Modular and Developmental Engineering Laboratory (REMODEL) Biomedical Sciences Building National University of Ireland Galway (NUI Galway) Galway Ireland
説明
<jats:title>Abstract</jats:title><jats:p>Collagen is the oldest and most abundant extracellular matrix protein that has found many applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview of the family of collagens and their respective structures, conformation, and biosynthesis is provided. The advances and shortfalls of various collagen preparations (e.g., mammalian/marine extracted collagen, cell‐produced collagens, recombinant collagens, and collagen‐like peptides) and crosslinking technologies (e.g., chemical, physical, and biological) are then critically discussed. Subsequently, an array of structural, thermal, mechanical, biochemical, and biological assays is examined, which are developed to analyze and characterize collagenous structures. Lastly, a comprehensive review is provided on how advances in engineering, chemistry, and biology have enabled the development of bioactive, 3D structures (e.g., tissue grafts, biomaterials, cell‐assembled tissue equivalents) that closely imitate native supramolecular assemblies and have the capacity to deliver in a localized and sustained manner viable cell populations and/or bioactive/therapeutic molecules. Clearly, collagens have a long history in both evolution and biotechnology and continue to offer both challenges and exciting opportunities in regenerative medicine as nature's biomaterial of choice.</jats:p>
収録刊行物
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- Advanced Materials
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Advanced Materials 31 (1), 1801651-, 2018-08-20
Wiley