Feasibility of transcatheter closure in unselected patients with secundum atrial septal defect, using amplatzer devices and a modified sizing balloon technique

<jats:title>Abstract</jats:title><jats:p><jats:styled-content>Objectives:</jats:styled-content> We aimed to assess (1) the role of surgical versus transcatheter closure techniques and (2) the impact of a modified implantation technique to optimize closure of secundum septal defects with the Amplatzer device. <jats:styled-content>Background:</jats:styled-content> Despite several comparative studies, the respective roles of surgical and transcatheter closure are not clarified. Additionally, the impact of modified method of implantation on device closure remains unknown. <jats:styled-content>Methods:</jats:styled-content> Fifty‐seven unselected patients were referred for secundum atrial septal defect closure in 2009, at a median age and weight of 27.5 (0.8–88) years and 40.6 (5.6–97) kg, respectively. Transcatheter closure was attempted in 53 cases under transesophagal echocardiography guidance in children (<jats:italic>n</jats:italic> = 28) and intracardiac echocardiography guidance in adults. If standard closure failed, a sizing balloon catheter inflated in the left atrium was used as a support to secure the position of the device upon deployment. <jats:styled-content>Results:</jats:styled-content> Fifty of the 57 cases (88%) were successfully closed with a median Amplatzer Septal Occluder size of 20 (10–40) mm, using the sizing balloon technique in eight (16%) cases. No major complication occurred. A trivial residual shunt remained in two patients (4%) whereas a mild mitral regurgitation appeared in one. By univariate analysis, a deficient superior–posterior rim and a large defect (>15 mm<jats:sup>2</jats:sup>/m<jats:sup>2</jats:sup>) were associated with the use of the sizing balloon technique (<jats:italic>P</jats:italic> = 0.04 and 0.03, respectively). A deficient superior–posterior rim and pulmonary hypertension were associated with failure to close the defect (<jats:italic>P</jats:italic> = 0.02 and 0.03, respectively). <jats:styled-content>Conclusion:</jats:styled-content> The majority of secundum atrial septal defect is amenable to transcatheter closure, using a modified implantation technique in 16% of cases. © 2011 Wiley‐Liss, Inc.</jats:p>