<jats:title>Summary</jats:title><jats:p>Professional antigen‐presenting cells (APC) are able to process and present exogenous antigen leading to the activation of T cells. Antigen–immunoglobulin (Ig)G complexes (IC) are much more efficiently processed and presented than soluble antigen. Dendritic cells (DC) are known for their ability to take up and process immune complex (IC) via FcγR, and they have been shown to play a crucial role in IC‐processing onto major histocompatibility complex (MHC) class I as they contain a specialized cross‐presenting transport system required for MHC class I antigen‐processing. However, the MHC class II‐antigen‐processing pathway is distinct. Therefore various other professional APC, like macrophages and B cells, all displaying FcγR, are thought to present IC‐delivered antigen in MHC class II. Nonetheless, the relative contribution of these APC in IC‐facilitated antigen‐presentation for MHC class II <jats:italic>in vivo</jats:italic> is not known. Here we show that, in mice, both macrophages and DC, but not B cells, efficiently capture IC. However, only DC, but not macrophages, efficiently activate antigen‐specific MHC class II restricted CD4<jats:sup>+</jats:sup> T cells. These results indicate that mainly DC and not other professional APC, despite expressing FcγR and MHC class II, contribute significantly to IC‐facilitated T cell activation <jats:italic>in vivo</jats:italic> under steady‐state conditions.</jats:p>