Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
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- Matthew L. Freedman
- Department of Medical Oncology, Dana–Farber Cancer Institute, Boston, MA 02115;
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- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089;
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- Nick Patterson
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
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- Gavin J. McDonald
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
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- Arti Tandon
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
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- Alicja Waliszewska
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
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- Kathryn Penney
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
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- Robert G. Steen
- Departments of eGenetics and
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- Kristin Ardlie
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
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- Esther M. John
- Northern California Cancer Center, Fremont, CA 94538;
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- Ingrid Oakley-Girvan
- Northern California Cancer Center, Fremont, CA 94538;
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- Alice S. Whittemore
- Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA 94305;
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- Kathleen A. Cooney
- Departments of Medicine and Urology and
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- Sue A. Ingles
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089;
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- David Altshuler
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
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- Brian E. Henderson
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089;
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- David Reich
- Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
書誌事項
- 公開日
- 2006-09-19
- DOI
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- 10.1073/pnas.0605832103
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:p> A whole-genome admixture scan in 1,597 African Americans identified a 3.8 Mb interval on chromosome 8q24 as significantly associated with susceptibility to prostate cancer [logarithm of odds (LOD) = 7.1]. The increased risk because of inheriting African ancestry is greater in men diagnosed before 72 years of age ( <jats:italic>P</jats:italic> < 0.00032) and may contribute to the epidemiological observation that the higher risk for prostate cancer in African Americans is greatest in younger men (and attenuates with older age). The same region was recently identified through linkage analysis of prostate cancer, followed by fine-mapping. We strongly replicated this association ( <jats:italic>P</jats:italic> < 4.2 × 10 <jats:sup>−9</jats:sup> ) but find that the previously described alleles do not explain more than a fraction of the admixture signal. Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 103 (38), 14068-14073, 2006-09-19
Proceedings of the National Academy of Sciences