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Complete Nucleotide Sequence and Genetic Organization of Aichi Virus, a Distinct Member of the <i>Picornaviridae</i> Associated with Acute Gastroenteritis in Humans
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- Teruo Yamashita
- <!--label omitted: 1-->Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi 462-8576,1 and
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- Naohisa Ishikawa
- <!--label omitted: 1-->Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi 462-8576,1 and
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- Tatsuo Miyamura
- <!--label omitted: 2-->Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640,2 Japan
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- Naokazu Takeda
- <!--label omitted: 2-->Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640,2 Japan
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- Yasumoto Suzuki
- <!--label omitted: 1-->Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi 462-8576,1 and
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- Hideaki Tsuzuki
- <!--label omitted: 1-->Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi 462-8576,1 and
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- Shudo Yamazaki
- <!--label omitted: 2-->Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640,2 Japan
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- Kenji Sakae
- <!--label omitted: 1-->Department of Virology, Aichi Prefectural Institute of Public Health, Nagoya, Aichi 462-8576,1 and
Bibliographic Information
- Published
- 1998-10
- Rights Information
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- https://journals.asm.org/non-commercial-tdm-license
- DOI
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- 10.1128/jvi.72.10.8408-8412.1998
- Publisher
- American Society for Microbiology
Search this article
Description
<jats:title>ABSTRACT</jats:title> <jats:p> The complete nucleotide sequence of a novel enteric virus, Aichi virus, associated with nonbacterial acute gastroenteritis in humans was determined. The Aichi virus genome proved to be a single-stranded positive-sense RNA molecule with 8,251 bases excluding a poly(A) tail; it contains a large open reading frame with 7,302 nucleotides that encodes a potential polyprotein precursor of 2,433 amino acids. The genome contains a 5′ nontranslated region (NTR) with 712 bases and a 3′ NTR with 240 bases followed by a poly(A) tail. The structure of the genome, VPg–5′ NTR–leader protein–structural proteins–nonstructural proteins–3′ NTR–poly(A), was found to be typical of a picornavirus. The VP0-VP3 and VP3-VP1 cleavage sites were determined to be Q-H and Q-T, respectively, by N-terminal amino acid sequence analyses using purified virion proteins. Possible cleavage sites, Q-G, Q-A, and Q-S, which cleave P2 and P3 polyproteins were found to be similar to those of picornaviruses. A dendrogram based on 3D <jats:sup>pol</jats:sup> proteins indicated that Aichi virus is genetically distinct from the known six genera of picornaviruses including entero-, rhino-, cardio-, aphtho-, and hepatovirus and echovirus 22. Considering this together with other properties of the virus (T. Yamashita, S. Kobayashi, K. Sakae, S. Nakata, S. Chiba, Y. Ishihara, and S. Isomura, J. Infect. Dis. 164:954–957, 1991), we propose that Aichi virus be regarded as a new genus of the family <jats:italic>Picornaviridae</jats:italic> . </jats:p>
Journal
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- Journal of Virology
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Journal of Virology 72 (10), 8408-8412, 1998-10
American Society for Microbiology
