Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis
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- Hideaki Kaneto
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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- Naoto Katakami
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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- Munehide Matsuhisa
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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- Taka-aki Matsuoka
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
書誌事項
- 公開日
- 2010
- 権利情報
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- http://creativecommons.org/licenses/by/3.0/
- DOI
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- 10.1155/2010/453892
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic -cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate -cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.</jats:p>
収録刊行物
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- Mediators of Inflammation
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Mediators of Inflammation 2010 1-11, 2010
Wiley