Structural similarities between topoisomerases that cleave one or both DNA strands
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- James M. Berger
- Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142; and Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138
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- Deborah Fass
- Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142; and Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138
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- James C. Wang
- Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142; and Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138
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- Stephen C. Harrison
- Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142; and Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138
説明
<jats:p>Type IA and type II DNA topoisomerases are distinguished by their ability to cleave one or two strands, respectively, of a DNA duplex. Both types have been proposed to use an “enzyme-bridging” mechanism, in which a break is formed in a DNA strand and a gap is opened between the broken pieces to allow passage of a second DNA strand or duplex segment. Although the type IA and type II topoisomerase structures appear overall quite different from one another, unexpected similarities between several structural elements suggest that members of the two subfamilies may use comparable mechanisms to bind and cleave DNA.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 95 (14), 7876-7881, 1998-07-07
Proceedings of the National Academy of Sciences
