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- LI-LI HSIAO
- Renal Division, Department of Medicine
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- FERNANDO DANGOND
- Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115
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- TAKUMI YOSHIDA
- Renal Division, Department of Medicine
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- ROBERT HONG
- Renal Division, Department of Medicine
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- RODERICK V. JENSEN
- Department of Physics, Wesleyan University, Middletown, Connecticut 06459
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- JATIN MISRA
- Bioinformatics and Metabolic Engineering Laboratory, Department of Chemical Engineering, Massachusetts Institutes of Technology, Cambridge, Massachusetts 01890
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- WILLIAM DILLON
- Renal Division, Department of Medicine
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- KAILIN F. LEE
- Renal Division, Department of Medicine
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- KATHRYN E. CLARK
- Renal Division, Department of Medicine
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- PETER HAVERTY
- Bioinformatics Program
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- ZHIPING WENG
- Department of Biomedical Engineering, Bioinformatics Program, Boston University, Boston 02215
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- GEORGE L. MUTTER
- Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115
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- MATTHEW P. FROSCH
- Center for Neurologic Diseases, and Division of Neuropathology, Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston 02115
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- MARCY E. MacDONALD
- Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown Massachusetts 02129
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- EDGAR L. MILFORD
- Renal Division, Department of Medicine
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- CHRISTOPHER P. CRUM
- Division of Women’s and Perinatal Pathology, Department of Pathology
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- RAPHAEL BUENO
- Division Thoracic Surgery
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- RICHARD E. PRATT
- Cardiovascular Division, Brigham and Women’s Hospital, Boston, Massachusetts 02115
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- MAMATHA MAHADEVAPPA
- Affymetrix, Inc., Santa Clara, California 95051
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- JANET A. WARRINGTON
- Affymetrix, Inc., Santa Clara, California 95051
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- GREGORY STEPHANOPOULOS
- Bioinformatics and Metabolic Engineering Laboratory, Department of Chemical Engineering, Massachusetts Institutes of Technology, Cambridge, Massachusetts 01890
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- GEORGE STEPHANOPOULOS
- Bioinformatics and Metabolic Engineering Laboratory, Department of Chemical Engineering, Massachusetts Institutes of Technology, Cambridge, Massachusetts 01890
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- STEVEN R. GULLANS
- Renal Division, Department of Medicine
書誌事項
- 公開日
- 2001-12-21
- DOI
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- 10.1152/physiolgenomics.00040.2001
- 公開者
- American Physiological Society
この論文をさがす
説明
<jats:p>This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of ∼7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org ) for future studies of pathophysiology.</jats:p>
収録刊行物
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- Physiological Genomics
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Physiological Genomics 7 (2), 97-104, 2001-12-21
American Physiological Society