The Biochemistry of Sirtuins

DOI Web Site 被引用文献21件
  • Anthony A. Sauve
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021;
  • Cynthia Wolberger
    Department of Biophysics and Biophysical Chemistry, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, Maryland 21205;
  • Vern L. Schramm
    Department of Biochemistry, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York 10465;
  • Jef D. Boeke
    Department of Molecular Biology and Genetics, Johns Hopkins University, Baltimore, Maryland 21205;

書誌事項

公開日
2006-06-01
DOI
  • 10.1146/annurev.biochem.74.082803.133500
公開者
Annual Reviews

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説明

<jats:p> Sirtuins are a family of NAD<jats:sup>+</jats:sup>-dependent protein deacetylases widely distributed in all phyla of life. Accumulating evidence indicates that sirtuins are important regulators of organism life span. In yeast, these unique enzymes regulate gene silencing by histone deacetylation and via formation of the novel compound 2′-O-acetyl-ADP-ribose. In multicellular organisms, sirtuins deacetylate histones and transcription factors that regulate stress, metabolism, and survival pathways. The chemical mechanism of sirtuins provides novel opportunities for signaling and metabolic regulation of protein deacetylation. The biological, chemical, and structural characteristics of these unusual enzymes are discussed in this review. </jats:p>

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