Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging
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- Dong-Hoon Hyun
- *Laboratory of Neurosciences and
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- Scott S. Emerson
- *Laboratory of Neurosciences and
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- Dong-Gyu Jo
- *Laboratory of Neurosciences and
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- Mark P. Mattson
- *Laboratory of Neurosciences and
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- Rafael de Cabo
- Laboratory of Experimental Gerontology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224; and
Abstract
<jats:p> The plasma membrane (PM) contains redox enzymes that provide electrons for energy metabolism and recycling of antioxidants such as coenzyme Q and α-tocopherol. Brain aging and neurodegenerative disorders involve impaired energy metabolism and oxidative damage, but the involvement of the PM redox system (PMRS) in these processes is unknown. Caloric restriction (CR), a manipulation that protects the brain against aging and disease, increased activities of PMRS enzymes (NADH-ascorbate free radical reductase, NADH-quinone oxidoreductase 1, NADH-ferrocyanide reductase, NADH-coenzyme Q10 reductase, and NADH-cytochrome <jats:italic>c</jats:italic> reductase) and antioxidant levels (α-tocopherol and coenzyme Q10) in brain PM during aging. Age-related increases in PM lipid peroxidation, protein carbonyls, and nitrotyrosine were attenuated by CR, levels of PMRS enzyme activities were higher, and markers of oxidative stress were lower in cultured neuronal cells treated with CR serum compared with those treated with ad libitum serum. These findings suggest important roles for the PMRS in protecting brain cells against age-related increases in oxidative and metabolic stress. </jats:p>
Journal
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 103 (52), 19908-19912, 2006-12-26
Proceedings of the National Academy of Sciences
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Details 詳細情報について
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- CRID
- 1363388845355871616
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- ISSN
- 10916490
- 00278424
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- Data Source
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- Crossref