-
- Vittoria Maresca
- Laboratory of Cutaneous Physiopathology and Integrated Centre of Metabolomics Research San Gallicano Dermatologic Institute Rome Italy
-
- Enrica Flori
- Laboratory of Cutaneous Physiopathology and Integrated Centre of Metabolomics Research San Gallicano Dermatologic Institute Rome Italy
-
- Mauro Picardo
- Laboratory of Cutaneous Physiopathology and Integrated Centre of Metabolomics Research San Gallicano Dermatologic Institute Rome Italy
説明
<jats:title>Summary</jats:title><jats:p>Cutaneous phototype is considered mainly related to cutaneous pigmentation and to the eumelanin/pheomelanin ratio, which is mostly genetically determined by the melanocortin 1 receptor (<jats:styled-content style="fixed-case">MC</jats:styled-content>1R) polymorphisms. However, data in literature indicate that, in addition to stimulation of eumelanin synthesis, the <jats:styled-content style="fixed-case">MC</jats:styled-content>1R signalling activates antioxidant, <jats:styled-content style="fixed-case">DNA</jats:styled-content> repair and survival pathways. New emerging aspects regarding photoprotection and skin phototypes are going beyond those features connected to the melanin content in the skin. Important new findings link the <jats:styled-content style="fixed-case">MC</jats:styled-content>1R to nuclear receptors activation, shedding light on new extra‐melanogenic effects dependent on the <jats:italic>α</jats:italic>‐melanocyte‐stimulating hormone (<jats:italic>α</jats:italic>‐<jats:styled-content style="fixed-case">MSH</jats:styled-content>) activity and new ways through which such functions are modulated. These evidences indicate that several factors including melanin play a part in defining the basis for individual sun sensitivity, suggesting that the cutaneous phototype represents a ‘biochemical fingerprint’.</jats:p>
収録刊行物
-
- Pigment Cell & Melanoma Research
-
Pigment Cell & Melanoma Research 28 (4), 378-389, 2015-04-11
Wiley
