Transoral laser microsurgery followed by radiation therapy for oropharyngeal tumors: The mayo clinic arizona experience
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- Samir H. Patel
- Department of Radiation Oncology Mayo Clinic Scottsdale Arizona
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- Michael L. Hinni
- Department of Otolaryngology Mayo Clinic Scottsdale Arizona
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- Richard E. Hayden
- Department of Otolaryngology Mayo Clinic Scottsdale Arizona
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- William W. Wong
- Department of Radiation Oncology Mayo Clinic Scottsdale Arizona
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- Amylou C. Dueck
- Department Biostatistics Mayo Clinic Scottsdale Arizona
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- Matthew A. Zarka
- Laboratory of Medicine‐Pathology Mayo Clinic Scottsdale Arizona
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- Kelly K. Curtis
- Division of Hematology/Oncology Mayo Clinic Scottsdale Arizona
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- Michele Y. Halyard
- Department of Radiation Oncology Mayo Clinic Scottsdale Arizona
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<jats:sec><jats:title>Background</jats:title><jats:p>The purpose of this study was to report the treatment outcomes of patients with advanced oropharyngeal cancer treated with transoral laser microsurgery (TLM) followed by radiation therapy (RT) at Mayo Clinic in Arizona.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A retrospective study of 80 patients treated from January 1, 2000 to November 7, 2011 was performed. All patients had stage III/IV oropharyngeal tumors and underwent TLM with neck dissection. Adjuvant RT was then given. Thirty‐seven patients received concurrent adjuvant chemotherapy. The primary outcome was locoregional control.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Median follow‐up was 47.3 months (range, 9.7–139.2 months). The 3‐year locoregional control, recurrence‐free survival, and overall survival rates were 98.6% (95% confidence interval [CI], 91% to 100%), 91.1% (95% CI, 81% to 96%), and 93.7% (95% CI, 84% to 98%), respectively. There were a total of 5 treatment failures, 1 regional and 4 distant. Twenty‐six patients underwent neck only RT with exclusion of the primary site.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>TLM followed by RT for advanced oropharyngeal cancer results in excellent locoregional control rates. © 2013 Wiley Periodicals, Inc. <jats:italic>Head Neck</jats:italic> 36: 220–225, 2014</jats:p></jats:sec>
収録刊行物
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- Head & Neck
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Head & Neck 36 (2), 220-225, 2013-03-26
Wiley
