説明
<jats:title>Abstract</jats:title><jats:p>The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.</jats:p>
収録刊行物
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- Signal Transduction and Targeted Therapy
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Signal Transduction and Targeted Therapy 2 (1), 17023-, 2017-07-14
Springer Science and Business Media LLC
