Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry

DOI Web Site 被引用文献3件
  • Jenn-Han Chen
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Yu-Wang Chang
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Chen-Wen Yao
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Tzong-Shi Chiueh
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Su-Chin Huang
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Ko-Yi Chien
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • An Chen
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Feng-Yee Chang
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Chi-Huey Wong
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037
  • Yu-Ju Chen
    School of Dentistry, Department of Pathology, and Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei 114, Taiwan; Institute of Chemistry and Genomics Research Center, Academia Sinica, Taipei 115, Taiwan; and The Scripps Research Institute, La Jolla, CA 92037

書誌事項

公開日
2004-11-30
DOI
  • 10.1073/pnas.0407992101
公開者
Proceedings of the National Academy of Sciences

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<jats:p>We have investigated the plasma proteome by using 2D gel electrophoresis and MS from patients with severe acute respiratory syndrome (SARS). A complete proteomic analysis was performed on four patients with SARS in different time courses, and a total of 38 differential spots were selected for protein identification. Most of the proteins identified are acute phase proteins, and their presence represents the consequence of serial cascades initiated by SARS-coronavirus infection. There are several proteins that have never been identified in plasma before using 2D gel electrophoresis, among which peroxiredoxin II was chosen for further study by analyzing additional 20 plasma samples from patients with probable and suspected SARS and patients with fever, respectively. The results showed that the level of plasma peroxiredoxin II in patients with SARS is significantly high and could be secreted by T cells. Taken together, our findings indicate that active innate immune responses, along with the oxidation-associated injuries, may play a major role in the pathogenesis of SARS.</jats:p>

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