Prostaglandin E <sub>2</sub> constrains systemic inflammation through an innate lymphoid cell–IL-22 axis

DOI HANDLE HANDLE Web Site 被引用文献14件 オープンアクセス
  • Rodger Duffin
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Richard A. O’Connor
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Siobhan Crittenden
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Thorsten Forster
    Division of Pathway Medicine, Edinburgh Infectious Diseases, The University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Cunjing Yu
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Xiaozhong Zheng
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Danielle Smyth
    Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh EH9 3JT, UK.
  • Calum T. Robb
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Fiona Rossi
    MRC Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh EH16 4UU, UK.
  • Christos Skouras
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Shaohui Tang
    Department of Gastroenterology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • James Richards
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Antonella Pellicoro
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Richard B. Weller
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Richard M. Breyer
    Department of Veterans Affairs, Tennessee Valley Health Authority, Nashville, TN 37212, USA.
  • Damian J. Mole
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • John P. Iredale
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Stephen M. Anderton
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Shuh Narumiya
    Center for Innovation in Immunoregulative Technology and Therapeutics (AK Project), Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
  • Rick M. Maizels
    Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh EH9 3JT, UK.
  • Peter Ghazal
    Division of Pathway Medicine, Edinburgh Infectious Diseases, The University of Edinburgh, Edinburgh EH16 4SB, UK.
  • Sarah E. Howie
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Adriano G. Rossi
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.
  • Chengcan Yao
    Medical Research Council (MRC) Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK.

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説明

<jats:title>A prostaglandin barrier to inflammation</jats:title> <jats:p> Blood-borne bacterial infections and severe trauma can send the immune system into overdrive, causing it to pump out inflammatory mediators, sometimes at lethal doses. Duffin <jats:italic>et al.</jats:italic> now report on a role for prostaglandins in keeping systemic inflammation in check. Systemic inflammation correlates with decreased production of the prostaglandin E2 (PGE2). Blocking PGE2 signaling in mice led to severe inflammation associated with the translocation of gut bacteria. PGE2 acts on innate lymphoid cells, which produce interleukin-22, a secreted protein that helps promote intestinal integrity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6279" page="1333" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad9903">1333</jats:related-article> </jats:p>

収録刊行物

  • Science

    Science 351 (6279), 1333-1338, 2016-03-18

    American Association for the Advancement of Science (AAAS)

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