Expression of the <i>TEL/EVI1</i> fusion transcript in a patient with chronic myelogenous leukemia with t(3;12)(q26;p13)
Description
<jats:title>Abstract</jats:title><jats:p>The t(3;12)(q26;p13) translocation is a recurrent chromosomal aberration observed in myeloid malignancies. It has been shown that the translocation results in the fusion of the <jats:italic>TEL (ETV6)</jats:italic> gene at 12p13 and the EV11 gene at 3q26. We report the first case with Philadelphia (Ph)‐positive chronic myelogenous leukemia (CML) expressing the <jats:italic>TEL/EVI1</jats:italic> fusion transcript. A 26‐year‐old man was initially diagnosed as having the chronic phase of Ph‐positive CML. The t(3;12)(q26;p13) emerged 16 months prior to the myeloid blastic crisis. Reverse transcriptase‐polymerase chain reaction detected the <jats:italic>TEL/EVI1</jats:italic> transcript without the intervening 5′ non‐coding exon of <jats:italic>EVI1</jats:italic>, suggesting that inappropriate expression of the EVI1 protein driven by the <jats:italic>TEL</jats:italic> promotor could play a critical role in progression to the blast crisis of CML. Am. J. Hematol. 69:80‐82, 2002. © 2002 Wiley‐Liss, Inc.</jats:p>
Journal
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- American Journal of Hematology
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American Journal of Hematology 69 (1), 80-82, 2001-12-20
Wiley
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Details 詳細情報について
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- CRID
- 1363388845607373440
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- ISSN
- 10968652
- 03618609
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- Data Source
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- Crossref