Glycemic Variability Correlates Strongly With Postprandialβ-Cell Dysfunction in a Segment of Type 2 Diabetic Patients Using Oral Hypoglycemic Agents
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- Klaus-Dieter Kohnert
- Institute of Diabetes “Gerhardt Katsch,” Karlsburg, Germany;
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- Petra Augstein
- Institute of Diabetes “Gerhardt Katsch,” Karlsburg, Germany;
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- Eckhard Zander
- Clinics for Diabetes and Metabolic Diseases, Karlsburg, Germany;
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- Peter Heinke
- Institute of Diabetes “Gerhardt Katsch,” Karlsburg, Germany;
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- Karolina Peterson
- Institute of Diabetes “Gerhardt Katsch,” Karlsburg, Germany;
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- Ernst-Joachim Freyse
- Institute of Diabetes “Gerhardt Katsch,” Karlsburg, Germany;
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- Roman Hovorka
- Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.
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- Eckhard Salzsieder
- Institute of Diabetes “Gerhardt Katsch,” Karlsburg, Germany;
Description
<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Glucose fluctuations trigger activation of oxidative stress, a main mechanism leading to secondary diabetes complications. We evaluated the relationship between glycemic variability and β-cell dysfunction.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>We conducted a cross-sectional study in 59 patients with type 2 diabetes (aged 64.2 ± 8.6 years, A1C 6.5 ± 1.0%, and BMI 29.8 ± 3.8 kg/m2[mean ± SD]) using either oral hypoglycemic agents (OHAs) (n = 34) or diet alone (nonusers). As a measure of glycemic variability, the mean amplitude of glycemic excursions (MAGE) was computed from continuous glucose monitoring data recorded over 3 consecutive days. The relationships between MAGE, β-cell function, and clinical parameters were assessed by including postprandial β-cell function (PBCF) and basal β-cell function (BBCF) obtained by a model-based method from plasma C-peptide and plasma glucose during a mixed-meal test as well as homeostasis model assessment of insulin sensitivity, clinical factors, carbohydrate intake, and type of OHA.</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>MAGE was nonlinearly correlated with PBCF (r = 0.54, P < 0.001) and with BBCF (r = 0.31, P = 0.025) in OHA users but failed to correlate with these parameters in nonusers (PBCF P = 0.21 and BBCF P = 0.07). The stepwise multiple regression analysis demonstrated that PBCF and OHA combination treatment were independent contributors to MAGE (R2 = 0.50, P < 0.010), whereas insulin sensitivity, carbohydrate intake, and nonglycemic parameters failed to contribute.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>PBCF appears to be an important target to reduce glucose fluctuations in OHA-treated type 2 diabetes.</jats:p> </jats:sec>
Journal
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- Diabetes Care
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Diabetes Care 32 (6), 1058-1062, 2009-02-24
American Diabetes Association
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Details 詳細情報について
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- CRID
- 1363388845638526080
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- ISSN
- 19355548
- 01495992
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- Data Source
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- Crossref