Changes of Neural Activity Correlate With the Severity of Cortical Ischemia in Patients With Unilateral Major Cerebral Artery Occlusion

DOI Web Site 被引用文献4件
  • Masahiko Bundo
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Suguru Inao
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Akinori Nakamura
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Takashi Kato
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Kengo Ito
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Masanori Tadokoro
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Ryusuke Kabeya
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Toru Sugimoto
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Yasukazu Kajita
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.
  • Jun Yoshida
    From the Department of Biofunctional Research, National Institute for Longevity Sciences, Ohbu, Japan (M.B., A.N., T.K., K.I., T.S.); the Department of Neurosurgery, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan (S.I., R.K.); and the Departments of Neurosurgery (Y.K., J.Y.) and Radiology (M.T.), Nagoya University School of Medicine, Nagoya, Japan.

説明

<jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Background and Purpose</jats:italic> </jats:bold> — </jats:italic> </jats:bold> In major cerebral arterial steno-occlusive diseases, there can be remarkably decreased hemodynamic reserve without marked neurological impairments. In such settings, it is not known whether the neural activity is well maintained or disturbed according to the severity of cerebral ischemia. The present study was therefore undertaken to examine the neural activity under mild cerebral ischemia resulting from major cerebral arterial occlusion. </jats:p> <jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Methods</jats:italic> </jats:bold> — </jats:italic> </jats:bold> Seven patients with minor neurological impairment as well as either unilateral internal carotid artery or middle cerebral artery occlusion were studied. The severity of the cortical ischemia was assessed by measuring regional cerebral blood flow (rCBF) with positron emission tomography. The change in neural activity in the ischemic brain was then evaluated by means of somatosensory evoked magnetic field with magnetoencephalography. </jats:p> <jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Results</jats:italic> </jats:bold> — </jats:italic> </jats:bold> The rCBF in the primary sensory area and the strength of the initial component of somatosensory evoked magnetic field (N20 m) were significantly reduced ( <jats:italic>P</jats:italic> <0.01) and the second component (P30 m) was significantly augmented ( <jats:italic>P</jats:italic> <0.05) in the lesioned cerebral hemisphere as compared with the nonlesioned hemisphere. The asymmetry indexes for N20 m were positively correlated ( <jats:italic>r</jats:italic> =0.78) and those for P30 m were inversely correlated ( <jats:italic>r</jats:italic> =−0.92) with asymmetry indexes for rCBF. </jats:p> <jats:p> <jats:bold> <jats:italic> <jats:bold> <jats:italic>Conclusions</jats:italic> </jats:bold> — </jats:italic> </jats:bold> In patients with either unilateral internal carotid artery or middle cerebral artery occlusion and minor neural impairments, there was a reduction of afferent signal and an augmentation of the secondary response of the neurons in the primary sensory area. This showed correlation with the severity of cortical ischemia. </jats:p>

収録刊行物

  • Stroke

    Stroke 33 (1), 61-66, 2002-01

    Ovid Technologies (Wolters Kluwer Health)

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