Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
-
- Peng Jin
- Department of Physiology, University of California, San Francisco, California 94158, USA;
-
- Lily Yeh Jan
- Department of Physiology, University of California, San Francisco, California 94158, USA;
-
- Yuh-Nung Jan
- Department of Physiology, University of California, San Francisco, California 94158, USA;
説明
<jats:p>Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to fit their biological roles. How mechanosensitive channels work, especially in animals, has been extensively studied in the past decade. Here we review key findings in the functional and structural characterizations of these channels and highlight the structural features relevant to the mechanotransduction mechanism of each specific channel.</jats:p>
収録刊行物
-
- Annual Review of Neuroscience
-
Annual Review of Neuroscience 43 (1), 207-229, 2020-07-08
Annual Reviews