Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms

DOI Web Site 8 Citations
  • Peng Jin
    Department of Physiology, University of California, San Francisco, California 94158, USA;
  • Lily Yeh Jan
    Department of Physiology, University of California, San Francisco, California 94158, USA;
  • Yuh-Nung Jan
    Department of Physiology, University of California, San Francisco, California 94158, USA;

Bibliographic Information

Published
2020-07-08
DOI
  • 10.1146/annurev-neuro-070918-050509
Publisher
Annual Reviews

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<jats:p>Activation of mechanosensitive ion channels underlies a variety of fundamental physiological processes that require sensation of mechanical force. Different mechanosensitive channels adapt distinctive structures and mechanotransduction mechanisms to fit their biological roles. How mechanosensitive channels work, especially in animals, has been extensively studied in the past decade. Here we review key findings in the functional and structural characterizations of these channels and highlight the structural features relevant to the mechanotransduction mechanism of each specific channel.</jats:p>

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