Evaluation of Left Atrial Appendage Functions in Patients with Thrombus and Spontaneous Echo Contrast in Left Atrial Appendage by Using Color Doppler Tissue Imaging

<jats:p> <jats:bold>Objective:</jats:bold> Thrombus and spontaneous echo contrast (SEC) develops in the left atrial appendage (LAA) when LAA function is disturbed. Decrease of left atrial appendage emptying velocity shows LAA dysfunction. The purpose of this study is to examine the incidence of SEC and/or thrombus in LAA in patients with acute myocardial infarction and to assess the LAA function using color Doppler tissue imaging (CDTI) of the patients with detected SEC and/or thrombus.</jats:p><jats:p> <jats:bold>Method and Results:</jats:bold> Eighty‐four patients with acute myocardial infarction were included in the study. Spontaneous echo contrast and/or thrombus were observed in 24 (29%) of the 84 patients who were categorized as group 1 (mean age 59 ± 12 years). Sixty patients (71%) without thrombus and/or SEC in LAA were categorized as group 2 (mean age 58 ± 8 years). Left atrial diameters and left ventricular ejection fraction were measured by using transthoracic echocardiography. Left atrial appendage emptying and LAA filling velocity were measured by transesophageal Doppler echocardiography. Systolic appendage tissue velocities (SaV cm/s) were measured at the basal, mid, and tip of medial wall of LAA by transesophageal CDTI. Group 1 had significantly decreased LAA emptying velocities, mid SaVs, and left ventricular ejection fractions compared to group 2 (37 ± 9 cm/s vs 55 ± 22 cm/s, 3.1 ± 1.6 cm/s vs 3.7 ± 1.2 cm/s, and 47 ± 13% vs 58 ± 10%, respectively, P = 0.002, P = 0.04, P = 0.03). Group 1 had significantly increased left atrial diameters compared to group 2 (40 ± 5 mm vs 36 ± 6 mm P = 0.001). Left atrial appendage‐filling velocities, basal SaVs and tip SaVs in group 1 were lower than those in group 2 but not significantly.</jats:p><jats:p> <jats:bold>Conclusions:</jats:bold> Mid‐SaV of LAA medial wall and LAA emptying velocity decrease in patients with thrombus and/or SEC were an indication of functional disorder of LAA. Color Doppler tissue imaging appears to be a clinically applicable and reliable imaging technique that allows quantitative assessment of regional LAA systolic function.</jats:p>