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- Ronald W. Irwin
- Department of Pharmacology and Pharmaceutical Sciences (R.W.I., J.Y., R.T.H., E.C., R.D.B., J.N.), University of Southern California, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California, 90033
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- Jia Yao
- Department of Pharmacology and Pharmaceutical Sciences (R.W.I., J.Y., R.T.H., E.C., R.D.B., J.N.), University of Southern California, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California, 90033
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- Ryan T. Hamilton
- Department of Pharmacology and Pharmaceutical Sciences (R.W.I., J.Y., R.T.H., E.C., R.D.B., J.N.), University of Southern California, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California, 90033
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- Enrique Cadenas
- Department of Pharmacology and Pharmaceutical Sciences (R.W.I., J.Y., R.T.H., E.C., R.D.B., J.N.), University of Southern California, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California, 90033
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- Roberta Diaz Brinton
- Department of Pharmacology and Pharmaceutical Sciences (R.W.I., J.Y., R.T.H., E.C., R.D.B., J.N.), University of Southern California, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California, 90033
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- Jon Nilsen
- Department of Pharmacology and Pharmaceutical Sciences (R.W.I., J.Y., R.T.H., E.C., R.D.B., J.N.), University of Southern California, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, California, 90033
説明
<jats:p>The ovarian hormones progesterone and estrogen have well-established neurotrophic and neuroprotective effects supporting both reproductive function and cognitive health. More recently, it has been recognized that these steroids also regulate metabolic functions sustaining the energetic demands of this neuronal activation. Underlying this metabolic control is an interpretation of signals from diverse environmental sources integrated by receptor-mediated responses converging upon mitochondrial function. In this study, to determine the effects of progesterone (P4) and 17β-estradiol (E2) on metabolic control via mitochondrial function, ovariectomized rats were treated with P4, E2, or E2 plus P4, and whole-brain mitochondria were isolated for functional assessment. Brain mitochondria from hormone-treated rats displayed enhanced functional efficiency and increased metabolic rates. The hormone-treated mitochondria exhibited increased respiratory function coupled to increased expression and activity of the electron transport chain complex IV (cytochrome c oxidase). This increased respiratory activity was coupled with a decreased rate of reactive oxygen leak and reduced lipid peroxidation representing a systematic enhancement of brain mitochondrial efficiency. As such, ovarian hormone replacement induces mitochondrial alterations in the central nervous system supporting efficient and balanced bioenergetics reducing oxidative stress and attenuating endogenous oxidative damage.</jats:p>
収録刊行物
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- Endocrinology
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Endocrinology 149 (6), 3167-3175, 2008-02-21
The Endocrine Society