The role of PDF neurons in setting the preferred temperature before dawn in Drosophila
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- Xin Tang
- Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States
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- Sanne Roessingh
- Department of Cell and Developmental Biology, University College London, London, United Kingdom
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- Sean E Hayley
- Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States
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- Michelle L Chu
- Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States
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- Nobuaki K Tanaka
- Creative Research Institution, Hokkaido University, Sapporo, Japan
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- Werner Wolfgang
- School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom
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- Seongho Song
- Department of Mathematical Sciences, University of Cincinnati, Cincinnati, United States
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- Ralf Stanewsky
- Department of Cell and Developmental Biology, University College London, London, United Kingdom
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- Fumika N Hamada
- Visual Systems Group, Abrahamson Pediatric Eye Institute, Division of Pediatric Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, United States
抄録
<jats:p>Animals have sophisticated homeostatic controls. While mammalian body temperature fluctuates throughout the day, small ectotherms, such as Drosophila achieve a body temperature rhythm (BTR) through their preference of environmental temperature. Here, we demonstrate that pigment dispersing factor (PDF) neurons play an important role in setting preferred temperature before dawn. We show that small lateral ventral neurons (sLNvs), a subset of PDF neurons, activate the dorsal neurons 2 (DN2s), the main circadian clock cells that regulate temperature preference rhythm (TPR). The number of temporal contacts between sLNvs and DN2s peak before dawn. Our data suggest that the thermosensory anterior cells (ACs) likely contact sLNvs via serotonin signaling. Together, the ACs-sLNs-DN2s neural circuit regulates the proper setting of temperature preference before dawn. Given that sLNvs are important for sleep and that BTR and sleep have a close temporal relationship, our data highlight a possible neuronal interaction between body temperature and sleep regulation.</jats:p>
収録刊行物
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- eLife
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eLife 6 e23206-, 2017-05-02
eLife Sciences Publications, Ltd