Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1

DOI Web Site 被引用文献16件
  • Stephen S. Hwang
    Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
  • Terence J. Boyle
    Department of Surgery, Duke University Medical Center, Durham, NC 27710.
  • H. Kim Lyerly
    Department of Surgery, Duke University Medical Center, Durham, NC 27710.
  • Bryan R. Cullen
    Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.

説明

<jats:p>Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line-tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.</jats:p>

収録刊行物

  • Science

    Science 253 (5015), 71-74, 1991-07-05

    American Association for the Advancement of Science (AAAS)

被引用文献 (16)*注記

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