Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1
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- Stephen S. Hwang
- Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
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- Terence J. Boyle
- Department of Surgery, Duke University Medical Center, Durham, NC 27710.
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- H. Kim Lyerly
- Department of Surgery, Duke University Medical Center, Durham, NC 27710.
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- Bryan R. Cullen
- Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
説明
<jats:p>Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line-tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.</jats:p>
収録刊行物
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- Science
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Science 253 (5015), 71-74, 1991-07-05
American Association for the Advancement of Science (AAAS)
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詳細情報 詳細情報について
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- CRID
- 1363388846139815168
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- NII論文ID
- 80005980749
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- ISSN
- 10959203
- 00368075
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- データソース種別
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