Prognosis for patients with CML and >10% BCR-ABL1 after 3 months of imatinib depends on the rate of BCR-ABL1 decline

  • Susan Branford
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • David T. Yeung
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Wendy T. Parker
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Nicola D. Roberts
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Leanne Purins
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Jodi A. Braley
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Haley K. Altamura
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Alexandra L. Yeoman
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Jasmina Georgievski
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Bronte A. Jamison
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Stuart Phillis
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Zoe Donaldson
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Mary Leong
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • Linda Fletcher
    Department of Genetics and Molecular Pathology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia;
  • John F. Seymour
    Australasian Leukaemia and Lymphoma Group, East Melbourne, Australia;
  • Andrew P. Grigg
    Australasian Leukaemia and Lymphoma Group, East Melbourne, Australia;
  • David M. Ross
    School of Medicine, and
  • Timothy P. Hughes
    School of Medicine, and

抄録

<jats:title>Key Points</jats:title><jats:p>Among patients with >10% BCR-ABL1, at 3 months, the poorest-risk group can be distinguished by the rate of BCR-ABL1 decline from baseline. Patients with BCR-ABL1 values on a constant downward trajectory may rapidly reach the level considered optimal with additional follow-up.</jats:p>

収録刊行物

  • Blood

    Blood 124 (4), 511-518, 2014-07-24

    American Society of Hematology

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