Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex
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- Tomasz J. Nowakowski
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Aparna Bhaduri
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Alex A. Pollen
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Beatriz Alvarado
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Mohammed A. Mostajo-Radji
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Elizabeth Di Lullo
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Maximilian Haeussler
- Genomics Institute, University of California, Santa Cruz, CA, USA.
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- Carmen Sandoval-Espinosa
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Siyuan John Liu
- The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA, USA.
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- Dmitry Velmeshev
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
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- Johain Ryad Ounadjela
- The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA, USA.
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- Joe Shuga
- New Technologies, Fluidigm, South San Francisco, CA, USA.
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- Xiaohui Wang
- New Technologies, Fluidigm, South San Francisco, CA, USA.
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- Daniel A. Lim
- The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, CA, USA.
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- Jay A. West
- New Technologies, Fluidigm, South San Francisco, CA, USA.
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- Anne A. Leyrat
- New Technologies, Fluidigm, South San Francisco, CA, USA.
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- W. James Kent
- Genomics Institute, University of California, Santa Cruz, CA, USA.
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- Arnold R. Kriegstein
- Department of Neurology, University of California, San Francisco (UCSF), San Francisco, CA, USA.
書誌事項
- 公開日
- 2017-12-08
- DOI
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- 10.1126/science.aap8809
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Building a brain</jats:title> <jats:p> The human brain is built in an inside-out manner as a series of layers. Although progenitor cells spin off new neurons in a seemingly organized fashion, the devil is in the details. Nowakowski <jats:italic>et al.</jats:italic> analyzed the transcriptomes of single cells from the developing brain to elucidate the hidden complexity of brain construction. For each cell, its position within the brain matters, as well as what type of neuron is being made at what point during overall development. These individual expression patterns result in organized diversity in the brain's cortex. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6368" page="1318" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aap8809">1318</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 358 (6368), 1318-1323, 2017-12-08
American Association for the Advancement of Science (AAAS)