Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation
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- Edward Y Woo
- Department of Surgery, University of Pennsylvania Medical Center , Philadelphia, PA 19104
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- Heidi Yeh
- Department of Surgery, University of Pennsylvania Medical Center , Philadelphia, PA 19104
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- Christina S Chu
- Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center , Philadelphia, PA 19104
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- Katia Schlienger
- Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center , Philadelphia, PA 19104
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- Richard G Carroll
- Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center , Philadelphia, PA 19104
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- James L Riley
- Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center , Philadelphia, PA 19104
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- Larry R Kaiser
- Department of Surgery, University of Pennsylvania Medical Center , Philadelphia, PA 19104
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- Carl H June
- Abramson Family Cancer Research Institute, University of Pennsylvania Medical Center , Philadelphia, PA 19104
書誌事項
- 公開日
- 2002-05-01
- 権利情報
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- https://academic.oup.com/pages/standard-publication-reuse-rights
- DOI
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- 10.4049/jimmunol.168.9.4272
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>Active suppression by T regulatory cells plays an important role in the down-regulation of T cell responses to foreign and self-Ags. Thus far, the potential role of CD4+CD25+ T cells in human tumors has not been reported. In this work we show that lung tumors contain large numbers of these cells and that they have constitutive high-level expression of CD152 (CTLA-4). Furthermore, the CD4+CD25+ T cells mediate potent inhibition of autologous T cell proliferation. Finally, regulatory T cells from patient tumors failed to inhibit the proliferation of allogeneic T cells. Together these results suggest that the CD4+CD25+ T cells found in lung tumors selectively inhibit the host immune response and therefore could contribute to the progression of lung cancer.</jats:p>
収録刊行物
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- The Journal of Immunology
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The Journal of Immunology 168 (9), 4272-4276, 2002-05-01
Oxford University Press (OUP)