Pancreatoduodenectomy for Distal Cholangiocarcinoma: Prognostic Impact of Lymph Node Metastasis

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  • Yoshiaki Murakami
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima University 1‐2‐3 Kasumi 734‐8551 Minami‐ku Hiroshima Japan
  • Kenichiro Uemura
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima University 1‐2‐3 Kasumi 734‐8551 Minami‐ku Hiroshima Japan
  • Yasuo Hayashidani
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima University 1‐2‐3 Kasumi 734‐8551 Minami‐ku Hiroshima Japan
  • Takeshi Sudo
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima University 1‐2‐3 Kasumi 734‐8551 Minami‐ku Hiroshima Japan
  • Hiroki Ohge
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima University 1‐2‐3 Kasumi 734‐8551 Minami‐ku Hiroshima Japan
  • Taijiro Sueda
    Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima University 1‐2‐3 Kasumi 734‐8551 Minami‐ku Hiroshima Japan

書誌事項

公開日
2006-09-07
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1007/s00268-006-0224-0
公開者
Wiley

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<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The aim of this study was to identify useful prognostic factors in patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The records of 36 patients with distal cholangiocarcinoma undergoing pancreatoduodenectomy were retrospectively reviewed. Potential clinicopathological prognostic factors that may affect survival were examined by univariate and multivariate analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>There was no mortality. Overall survival rates were 75%, 54%, and 50% for 1, 3 and 5 years, respectively (median survival time, 26 months). Univariate analysis found that age (≧ 65 years), pancreatic invasion, duodenal invasion, lymph node metastasis, perineural invasion and a positive surgical margin were significant predictors of poor prognosis (<jats:italic>P</jats:italic> < 0.05). Furthermore, lymph node metastasis was found to be a significant independent predictor of poor prognosis by multivariate analysis (<jats:italic>P</jats:italic> = 0.043). Moreover, there were significant differences in the 5‐year survival between patients with 2 or less involved lymph nodes and those with 3 or more positive nodes (<jats:italic>P</jats:italic> < 0.001). There were no 2‐year survivors of the group of patients with 3 or more positive nodes.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These results suggest that the presence and number of lymph nodes exhibiting metastatic disease might be useful in predicting the postsurgical outcome in patients undergoing pancreatoduodenectomy for distal cholangiocarcinoma.</jats:p></jats:sec>

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