Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85

DOI Web Site 被引用文献7件
  • Arie Kaffman
    School of Medicine, Department of Biochemistry and Biophysics, University of California at San Francisco (UCSF), San Francisco, CA 94143, USA.
  • Ira Herskowitz
    School of Medicine, Department of Biochemistry and Biophysics, University of California at San Francisco (UCSF), San Francisco, CA 94143, USA.
  • Robert Tjian
    School of Medicine, Department of Biochemistry and Biophysics, University of California at San Francisco (UCSF), San Francisco, CA 94143, USA.
  • Erin K. O'Shea
    School of Medicine, Department of Biochemistry and Biophysics, University of California at San Francisco (UCSF), San Francisco, CA 94143, USA.

書誌事項

公開日
1994-02-25
DOI
  • 10.1126/science.8108735
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> Induction of the yeast gene <jats:italic>PHO5</jats:italic> is mediated by the transcription factors PHO2 and PHO4. <jats:italic>PHO5</jats:italic> transcription is not detectable in high phosphate; it is thought that the negative regulators PHO80 and PHO85 inactivate PHO2 and PHO4. Here it is reported that PHO80 has homology to yeast cyclins and interacts with PHO85, a p34 <jats:sup>cdc2/CDC28</jats:sup> -related protein kinase. The PHO80-PHO85 complex phosphorylates PHO4; this phosphorylation is correlated with negative regulation of <jats:italic>PHO5</jats:italic> . These results demonstrate the existence of a cyclin-cdk complex that is used for a regulatory process other than cell-cycle control and identify a physiologically relevant substrate for this complex. </jats:p>

収録刊行物

  • Science

    Science 263 (5150), 1153-1156, 1994-02-25

    American Association for the Advancement of Science (AAAS)

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