Alpha-Toxin of<i>Clostridium perfringens</i>Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens
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- Anthony L. Keyburn
- Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Australia
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- Scott A. Sheedy
- Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Australia
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- Mark E. Ford
- Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Australia
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- Mark M. Williamson
- Gribbles Veterinary Pathology, Clayton 3168, Australia
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- Milena M. Awad
- Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton 3800, Australia
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- Julian I. Rood
- Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Department of Microbiology, Monash University, Clayton 3800, Australia
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- Robert J. Moore
- Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Australia
抄録
<jats:title>ABSTRACT</jats:title><jats:p>The<jats:italic>Clostridium perfringens</jats:italic>alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.</jats:p>
収録刊行物
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- Infection and Immunity
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Infection and Immunity 74 (11), 6496-6500, 2006-11
American Society for Microbiology
