Cellular and molecular mechanisms underlying presynapse formation

  • Poh Hui Chia
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 1
  • Pengpeng Li
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 1
  • Kang Shen
    Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305 1

書誌事項

公開日
2013-10-14
DOI
  • 10.1083/jcb.201307020
公開者
Rockefeller University Press

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説明

<jats:p>Synapse formation is a highly regulated process that requires the coordination of many cell biological events. Decades of research have identified a long list of molecular components involved in assembling a functioning synapse. Yet how the various steps, from transporting synaptic components to adhering synaptic partners and assembling the synaptic structure, are regulated and precisely executed during development and maintenance is still unclear. With the improvement of imaging and molecular tools, recent work in vertebrate and invertebrate systems has provided important insight into various aspects of presynaptic development, maintenance, and trans-synaptic signals, thereby increasing our understanding of how extrinsic organizers and intracellular mechanisms contribute to presynapse formation.</jats:p>

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