Phylogenetic network analysis of SARS-CoV-2 genomes

  • Peter Forster
    Institute of Forensic Genetics, 48161 Münster, Germany;
  • Lucy Forster
    Lakeside Healthcare Group at Cedar House Surgery, St Neots PE19 1BQ, United Kingdom;
  • Colin Renfrew
    McDonald Institute for Archaeological Research, University of Cambridge, Cambridge CB2 3ER, United Kingdom;
  • Michael Forster
    Fluxus Technology Limited, Colchester CO3 0NU, United Kingdom;

説明

<jats:title>Significance</jats:title> <jats:p>This is a phylogenetic network of SARS-CoV-2 genomes sampled from across the world. These genomes are closely related and under evolutionary selection in their human hosts, sometimes with parallel evolution events, that is, the same virus mutation emerges in two different human hosts. This makes character-based phylogenetic networks the method of choice for reconstructing their evolutionary paths and their ancestral genome in the human host. The network method has been used in around 10,000 phylogenetic studies of diverse organisms, and is mostly known for reconstructing the prehistoric population movements of humans and for ecological studies, but is less commonly employed in the field of virology.</jats:p>

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