Asymmetric Brønsted Acid‐Catalyzed Friedel–Crafts Reactions of Indoles with Cyclic Imines ‐ Efficient Generation of Nitrogen‐Substituted Quaternary Carbon Centers

Magnus Rueping, Sadiya Raja, Alberto Núñez

doi:10.1002/adsc.201000952

Asymmetric Brønsted Acid‐Catalyzed Friedel–Crafts Reactions of Indoles with Cyclic Imines ‐ Efficient Generation of Nitrogen‐Substituted Quaternary Carbon Centers

DOI Web Site Web Site 被引用文献6件

書誌事項

公開日: 2011-03-02

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/adsc.201000952

公開者: Wiley

この論文をさがす

CiNii Books

説明

<jats:title>Abstract</jats:title><jats:p>A new enantioselective Brønsted acid‐catalyzed Friedel–Crafts reaction of indole with cyclic imines has been develeoped. This organocatalytic reaction provides for the first time optically active indolindolinone derivatives in high yields and with excellent enantioselectivities (up to 91% <jats:italic>ee</jats:italic>) under mild reaction conditions.</jats:p>