Calcium Signaling Through CatSper Channels in Mammalian Fertilization

DOI Web Site 4 Citations
  • Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania
  • Jingsheng Xia
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania

Description

<jats:p>The molecular mechanisms underlying Ca<jats:sup>2+</jats:sup>entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility. We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca<jats:sup>2+</jats:sup>entry through CatSper channels instead of acting on Ca<jats:sub>V</jats:sub>and CNG channels as previously thought.</jats:p>

Journal

  • Physiology

    Physiology 25 (3), 165-175, 2010-06

    American Physiological Society

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