An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging

  • Liang Gao
    Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
  • Ya Zhang
    Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
  • Lina Zhao
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
  • Wenchao Niu
    Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
  • Yuhua Tang
    Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
  • Fuping Gao
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
  • Pengju Cai
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
  • Qing Yuan
    Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
  • Xiayan Wang
    Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.
  • Huaidong Jiang
    School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
  • Xueyun Gao
    Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing 100124, China.

書誌事項

公開日
2020-07-17
権利情報
  • https://creativecommons.org/licenses/by-nc/4.0/
DOI
  • 10.1126/sciadv.abb1421
公開者
American Association for the Advancement of Science (AAAS)

説明

<jats:p>A metal cluster stuck in a protein acts as a synthetic metalloenzyme for cancer-specific catalytic therapy.</jats:p>

収録刊行物

  • Science Advances

    Science Advances 6 (29), eabb1421-, 2020-07-17

    American Association for the Advancement of Science (AAAS)

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