Validating the AMRFinder Tool and Resistance Gene Database by Using Antimicrobial Resistance Genotype-Phenotype Correlations in a Collection of Isolates

  • Michael Feldgarden
    National Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Vyacheslav Brover
    National Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Daniel H. Haft
    National Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Arjun B. Prasad
    National Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Douglas J. Slotta
    National Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Igor Tolstoy
    National Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
  • Gregory H. Tyson
    Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA
  • Shaohua Zhao
    Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA
  • Chih-Hao Hsu
    Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA
  • Patrick F. McDermott
    Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA
  • Daniel A. Tadesse
    Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, Maryland, USA
  • Cesar Morales
    USDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA
  • Mustafa Simmons
    USDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA
  • Glenn Tillman
    USDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA
  • Jamie Wasilenko
    USDA Food Safety and Inspection Service, Office of Public Health Science, Eastern Laboratory, Athens, Georgia, USA
  • Jason P. Folster
    Enteric Diseases Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
  • William Klimke
    National Center for Biological Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA

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<jats:p>Antimicrobial resistance (AMR) is a major public health problem that requires publicly available tools for rapid analysis. To identify AMR genes in whole-genome sequences, the National Center for Biotechnology Information (NCBI) has produced AMRFinder, a tool that identifies AMR genes using a high-quality curated AMR gene reference database.</jats:p>

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