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- D J Byrne
- Department of Surgery, Ninewells Hospital and Medical School , Dundee DD1 9SY,
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- M C K Browning
- Department of Biochemical Medicine, Ninewells Hospital and Medical School , Dundee DD1 9SY,
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- A Cuschieri
- Department of Surgery, Ninewells Hospital and Medical School , Dundee DD1 9SY,
書誌事項
- 公開日
- 1990-09-01
- 権利情報
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- https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
- DOI
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- 10.1002/bjs.1800770918
- 公開者
- Oxford University Press (OUP)
この論文をさがす
説明
<jats:title>Abstract</jats:title> <jats:p>To date, tumour markers for gastric cancer have proved unreliable. In this study the value of a new serum marker, CA 72–4, was compared with the serum activities of carcinoembryonic antigen (CEA) and CA19-9 in a consecutive series of patients with gastric cancer. The results show that the CAT2-4 assay is significantly better at separating stage I and II disease from normal controls (P < 0·01) than CEA (n.s.) or CA19-9 (n.s.). CA72-4 also gave better differentiation between patients with positive and negative nodes (P < 0·01) and between those who were serosa positive and negative (P < 0·01). CEA differentiated between patients with positive and negative nodes (P < 0·05) but CA19-9 could not. CA19-9 and CEA could not discriminate between patients who were serosa positive and negative. In this study, at a specificity of 95 per cent, the sensitivities of CEA, C A19-9 and CA72-4 were 0·25, 0·41 and 0·94 respectively. These preliminary findings indicate that CA 72-4 is a reliable tumour marker of disease stage and activity in gastric cancer. Further longitudinal studies are required for full evaluation of its clinical utility.</jats:p>
収録刊行物
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- Journal of British Surgery
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Journal of British Surgery 77 (9), 1010-1013, 1990-09-01
Oxford University Press (OUP)