Differences in Rat Models Used in Routine Toxicity Studies

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  • Klaus Weber
    AnaPath GmbH, Buchsweg 56, 4625 Oberbuchsiten, Switzerland
  • Tanja Razinger
    Harlan Laboratories Ltd, Zelgliweg 1, 4452 Itingen, Switzerland
  • Jerry F. Hardisty
    EPL Experimental Pathology Laboratories Inc., Research Triangle Park, NC, USA
  • Peter Mann
    EPL Experimental Pathology Laboratories Inc., Seattle, WA, USA
  • Kellie C. Martel
    Harlan Laboratories Ltd, 8520 Allison Pointe Blvd, Indianapolis, IN, USA
  • Emily A. Frische
    Harlan Laboratories Ltd, 8520 Allison Pointe Blvd, Indianapolis, IN, USA
  • Kai Blumbach
    Harlan Laboratories Ltd, Zelgliweg 1, 4452 Itingen, Switzerland
  • Stephen Hillen
    Harlan Laboratories Ltd, Harlan Laboratories France Ltd, Avenue des Portes Occitanes, 03800 Gannat, France
  • SeungWoo Song
    Harlan Korea Co. Ltd, 30th floor, ASEM tower, 159-1, Samsung-dong, Kangnam-ku, Seoul, 135-798, South Korea
  • Takayuki Anzai
    Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo, Japan
  • Hans-Jörg Chevalier
    AnaPath GmbH, Buchsweg 56, 4625 Oberbuchsiten, Switzerland

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<jats:p> The discussion on whether the Sprague Dawley (SD), the Fischer F344, or the Hannover Wistar rat is the most appropriate model for toxicity studies in rodents is ongoing. A substantial quantity of data on these strains concerning their source, diet, and housing conditions have been published. Generally, before starting a toxicology program in rodents, it should be taken into account that oncogenicity studies will be required for the majority of compounds successfully completing development. Survival, body weight development, incidence, type, time of onset of age-dependent lesions and neoplasms, as well as some special considerations of the rat model selected may be decisive. Therefore, an understanding of the historical background data is essential. These aspects demonstrate why the use of a specific rat model should be carefully considered at the beginning of the toxicology program. </jats:p>

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