Comparative genome analysis of <i>Salmonella</i> Enteritidis PT4 and <i>Salmonella</i> Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways
書誌事項
- 公開日
- 2008-06-26
- DOI
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- 10.1101/gr.077404.108
- 公開者
- Cold Spring Harbor Laboratory
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説明
<jats:p>We have determined the complete genome sequences of a host-promiscuous <jats:italic>Salmonella enterica</jats:italic> serovar Enteritidis PT4 isolate P125109 and a chicken-restricted <jats:italic>Salmonella enterica</jats:italic> serovar Gallinarum isolate 287/91. Genome comparisons between these and other <jats:italic>Salmonella</jats:italic> isolates indicate that <jats:italic>S</jats:italic>. Gallinarum 287/91 is a recently evolved descendent of <jats:italic>S.</jats:italic> Enteritidis. Significantly, the genome of <jats:italic>S</jats:italic>. Gallinarum has undergone extensive degradation through deletion and pseudogene formation. Comparison of the pseudogenes in <jats:italic>S</jats:italic>. Gallinarum with those identified previously in other host-adapted bacteria reveals the loss of many common functional traits and provides insights into possible mechanisms of host and tissue adaptation. We propose that experimental analysis in chickens and mice of <jats:italic>S</jats:italic>. Enteritidis–harboring mutations in functional homologs of the pseudogenes present in <jats:italic>S.</jats:italic> Gallinarum could provide an experimentally tractable route toward unraveling the genetic basis of host adaptation in <jats:italic>S. enterica</jats:italic>.</jats:p>
収録刊行物
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- Genome Research
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Genome Research 18 (10), 1624-1637, 2008-06-26
Cold Spring Harbor Laboratory