書誌事項
- 公開日
- 2000
- 権利情報
-
- http://creativecommons.org/licenses/by/3.0/
- DOI
-
- 10.1002/1097-0061(20000930)17:3<170::aid-yea25>3.0.co;2-v
- 公開者
- Hindawi Limited
この論文をさがす
説明
<jats:p>We propose a scheme for the origin of mitochondria based on phylogenetic reconstructions with more than 400 yeast nuclear genes that encode mitochondrial proteins. Half of the yeast mitochondrial proteins have no discernable bacterial homologues, while one-tenth are unequivocally of α-proteobacterial origin. These data suggest that the majority of genes encoding yeast mitochondrial proteins are descendants of two different genomic lineages that have evolved in different modes. First, the ancestral free-living α-proteobacterium evolved into an endosymbiont of an anaerobic host. Most of the ancestral bacterial genes were lost, but a small fraction of genes supporting bioenergetic and translational processes were retained and eventually transferred to what became the host nuclear genome. In a second, parallel mode, a larger number of novel mitochondrial genes were recruited from the nuclear genome to complement the remaining genes from the bacterial ancestor. These eukaryotic genes, which are primarily involved in transport and regulatory functions, transformed the endosymbiont into an ATP-exporting organelle.</jats:p>
収録刊行物
-
- Yeast
-
Yeast 1 (3), 170-187, 2000
Hindawi Limited
