Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action

DOI PDF XML 被引用文献2件
  • Humberto Nicastro
    Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, Brazil
  • Claudia Ribeiro da Luz
    Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, Brazil
  • Daniela Fojo Seixas Chaves
    Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, Brazil
  • Luiz Roberto Grassmann Bechara
    Laboratory of Molecular and Cellular Physiology of Exercise, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030, São Paulo, SP, Brazil
  • Vanessa Azevedo Voltarelli
    Laboratory of Molecular and Cellular Physiology of Exercise, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030, São Paulo, SP, Brazil
  • Marcelo Macedo Rogero
    Department of Nutrition, School of Public Health, University of São Paulo, P.O. Box 01246-904, São Paulo, SP, Brazil
  • Antonio Herbert Lancha
    Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, P.O. Box 05508-030 São Paulo, SP, Brazil

書誌事項

公開日
2012
権利情報
  • http://creativecommons.org/licenses/by/3.0/
DOI
  • 10.1155/2012/136937
公開者
Wiley

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説明

<jats:p>Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation. The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis. Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages. The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation.</jats:p>

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