Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides

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  • Zhenfu Han
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Jerome S. Pinkner
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Bradley Ford
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Erik Chorell
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Jan M. Crowley
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Corinne K. Cusumano
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Scott Campbell
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Jeffrey P. Henderson
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • Scott J. Hultgren
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States
  • James W. Janetka
    Department of Biochemistry and Molecular Biophysics, ‡Department of Molecular Microbiology, §Department of Pathology and Immunology, ∥Center for Women’s Infectious Disease Research, ⊥Department of Internal Medicine, and #Department of Anesthesiology, Washington University School of Medicine, 660 S. Euclid Avenue, Saint Louis, Missouri 63110, United States

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